diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/HistoryTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/HistoryTest.kt
index c9a8bc177..468cbd903 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/HistoryTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/HistoryTest.kt
@@ -11,6 +11,7 @@ import mozilla.components.browser.storage.sync.PlacesHistoryStorage
 import okhttp3.mockwebserver.MockWebServer
 import org.junit.After
 import org.junit.Before
+import org.junit.Ignore
 import org.junit.Rule
 import org.junit.Test
 import org.mozilla.fenix.helpers.AndroidAssetDispatcher
@@ -224,6 +225,7 @@ class HistoryTest {
         }
     }
 
+    @Ignore("Intermittent failures: https://github.com/mozilla-mobile/fenix/issues/10642")
     @Test
     fun openHistoryInPrivateTabTest() {
         val firstWebPage = TestAssetHelper.getGenericAsset(mockWebServer, 1)
@@ -244,6 +246,7 @@ class HistoryTest {
         }
     }
 
+    @Ignore("Intermittent failures: https://github.com/mozilla-mobile/fenix/issues/10642")
     @Test
     fun deleteMultipleSelectionTest() {
         val firstWebPage = TestAssetHelper.getGenericAsset(mockWebServer, 1)
diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/NavigationToolbarTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/NavigationToolbarTest.kt
index 238d4c0e4..0b650b288 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/NavigationToolbarTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/NavigationToolbarTest.kt
@@ -95,6 +95,7 @@ class NavigationToolbarTest {
         }
     }
 
+    @Ignore("Intermittent failures: https://github.com/mozilla-mobile/fenix/issues/10642")
     @Test
     fun refreshPageTest() {
         val refreshWebPage = TestAssetHelper.getRefreshAsset(mockWebServer)
diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/SettingsAboutTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/SettingsAboutTest.kt
index 26368bd0a..fd54a7502 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/SettingsAboutTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/SettingsAboutTest.kt
@@ -10,6 +10,7 @@ import okhttp3.mockwebserver.MockWebServer
 import org.junit.Rule
 import org.junit.Before
 import org.junit.After
+import org.junit.Ignore
 import org.junit.Test
 import org.mozilla.fenix.helpers.AndroidAssetDispatcher
 import org.mozilla.fenix.helpers.HomeActivityIntentTestRule
@@ -69,6 +70,7 @@ class SettingsAboutTest {
 
     }
 
+    @Ignore("Instrumentation crash: https://github.com/mozilla-mobile/fenix/issues/11642")
     @Test
     fun verifyAboutFirefoxPreview() {
         homeScreen {
diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/StrictEnhancedTrackingProtectionTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/StrictEnhancedTrackingProtectionTest.kt
index 5ac044f6c..d3a987aee 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/StrictEnhancedTrackingProtectionTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/StrictEnhancedTrackingProtectionTest.kt
@@ -8,6 +8,7 @@ import androidx.test.platform.app.InstrumentationRegistry
 import okhttp3.mockwebserver.MockWebServer
 import org.junit.After
 import org.junit.Before
+import org.junit.Ignore
 import org.junit.Rule
 import org.junit.Test
 import org.mozilla.fenix.ext.settings
@@ -156,6 +157,7 @@ class StrictEnhancedTrackingProtectionTest {
         }
     }
 
+    @Ignore("Instrumentation crash: https://github.com/mozilla-mobile/fenix/issues/11642")
     @Test
     fun testStrictVisitDisableExceptionToggle() {
         val trackingProtectionTest =
diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/TabbedBrowsingTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/TabbedBrowsingTest.kt
index da851ffa6..6f036aa4a 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/TabbedBrowsingTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/TabbedBrowsingTest.kt
@@ -56,6 +56,7 @@ class TabbedBrowsingTest {
         mockWebServer.shutdown()
     }
 
+    @Ignore("Intermittent failures: https://github.com/mozilla-mobile/fenix/issues/10642")
     @Test
     fun openNewTabTest() {
         homeScreen { }.dismissOnboarding()
@@ -75,6 +76,7 @@ class TabbedBrowsingTest {
         }
     }
 
+    @Ignore("Intermittent failures: https://github.com/mozilla-mobile/fenix/issues/10642")
     @Test
     fun openNewPrivateTabTest() {
         homeScreen { }.dismissOnboarding()
diff --git a/app/src/androidTest/java/org/mozilla/fenix/ui/ThreeDotMenuMainTest.kt b/app/src/androidTest/java/org/mozilla/fenix/ui/ThreeDotMenuMainTest.kt
index 1349dcebe..009f38a77 100644
--- a/app/src/androidTest/java/org/mozilla/fenix/ui/ThreeDotMenuMainTest.kt
+++ b/app/src/androidTest/java/org/mozilla/fenix/ui/ThreeDotMenuMainTest.kt
@@ -9,6 +9,7 @@ import androidx.test.uiautomator.UiDevice
 import okhttp3.mockwebserver.MockWebServer
 import org.junit.After
 import org.junit.Before
+import org.junit.Ignore
 import org.junit.Rule
 import org.junit.Test
 import org.mozilla.fenix.helpers.AndroidAssetDispatcher
@@ -42,6 +43,7 @@ class ThreeDotMenuMainTest {
         mockWebServer.shutdown()
     }
 
+    @Ignore("Instrumentation crash: https://github.com/mozilla-mobile/fenix/issues/11642")
     @Test
     fun threeDotMenuItemsTest() {
         homeScreen {